Death is sin rendered visible. What we see death do to the body, sin does to the soul. Death is the externalizing of sin. Death is no friend. Apart from Christ, the Bible sees death as the realm where God is not praised. As the bitter fruit of sin, death is the enemy; indeed, it is the “last enemy,” says 1 Corinthians 15:26. When the psalmist, then, prays for deliverance from death, he is talking about a great deal more than a physical phenomenon. Death is the “last enemy,” the physical symbol of our sinful alienation from God: “For in death there is no memory of You; in the grave, who will give You thanks?”
— Patrick Henry Reardon, Christ in the Psalms, 12.